The protease appears particularly selective at the P1 position, tolerating only cysteine, glycine, serine or the wild-type residue alanine
Early signs commonly include nighttime tingling, numbness, burning, or pain in the thumb, index finger, middle finger, and part of the ring finger
318,319,320 Furthermore, stability can be improved without compromising drug activity by optimizing the number and modification positions of 2-F and 2-OME groups on both strands of double-stranded siRNA, leading to substantial efficacy improvements
This can be somewhat useful for healthier people, because it is reliant on the strength of that individuals ability to make glutathione
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model